英雄航天员景海鹏、陈冬与复旦师生分享航天梦

Neglected diseases significantly impact the world, and there is a lack of effective treatments, requiring therapeutic alternatives. Thus, the study of the phytochemical and schistosomicidal activity evaluation of Copaifera oblongifolia leaves’ crude extract was conducted. The quercitrin (1) and afzelin (2) were isolated from the crude extract. In the in vitro schistosomicidal activity test, the isolated compounds demonstrated promising results, with 75% mortality at a concentration of 12.5 µM after 72 h. Molecular docking calculations indicated that compounds 1 and 2 could potentially interact with the amino acids of the FAD binding site in the TGR enzyme, a crucial enzyme for the survival of Schistosoma mansoni. These interactions could have binding energies comparable to praziquantel, a preferred drug for treating schistosomiasis. Therefore, in silico and in vitro investigations are crucial for developing new studies that can reveal the antiparasitic potential of compounds of plant origin. Full article

Edible mushrooms are well-known for their culinary and nutritional values. Additionally, they serve as a natural source of polyphenols, a group of bioactive compounds that significantly treat diseases associated with oxidative stress. The polyphenolic profile of mushrooms mainly consists of phenolic acids and flavonoids, whose chemical properties have attracted the attention of both the food and pharmaceutical industries. Consequently, methods for extracting polyphenols from mushrooms encompass conventional techniques (maceration and Soxhlet extraction) as well as innovative or green methods (ultrasound-assisted extraction, microwave-assisted extraction, pressurized liquid extraction, supercritical fluid extraction, enzyme-assisted extraction, and pulsed electric field extraction). Nonetheless, extraction with pressurized liquids and supercritical fluids is considered the most suitable method, as they function in a gentle and selective manner, preserving the integrity of the phenolic compounds. The use of mushroom-derived phenolic compounds in food and pharmaceutical formulations continues to face challenges concerning the safety of these extracts, as they might contain unwanted substances. Future applications should incorporate purification systems to yield highly pure extracts, thereby creating safe polyphenol carriers (for food and pharmaceutical products) for consumers. Full article

An important property of arylboronic acids, particularly when considering their use in medicinal chemistry, is their pK_a in aqueous solution. The results of computational determination of absolute pK_as of arylboronic acids can be very disappointing in comparison to available experimental results, particularly in the case of large substituents. In this paper, the main origin of this problem is identified. It is shown that in order to obtain accurate pK_a values for arylboronic acids from computational quantum chemistry, it is necessary to consider the effect of different possible conformations of the hydroxyl groups in the acid and its conjugate base together with the low-energy conformations of their substituents. An improved practical procedure for the computational determination of the pK_as of arylboronic acids is proposed and applied to a set of recently synthesized arylboronic acids, yielding consistent results. Full article

Multilayer thin films composed of cobalt (Co), carbon (C), and chromium (Cr) possess promising electromagnetic properties, yet the combined Co–C–Cr system remains underexplored, particularly regarding its performance as a microwave absorber. Existing research has primarily focused on binary Co–C or Co–Cr compositions, leaving a critical knowledge gap in understanding how ternary multilayer architectures influence electromagnetic behavior. This study addresses this gap by investigating the structure, phase composition, and microwave absorption performance of Co–C–Cr multilayer coatings fabricated via magnetron sputtering onto porous silicon substrates. This study compares four-layer and eight-layer configurations to assess how multilayer architecture affects impedance matching, reflection coefficients, and absorption characteristics within the 8.2–12.4 GHz frequency range. Structural analyses using X-ray diffraction and transmission electron microscopy confirm the coexistence of amorphous and nanocrystalline phases, which enhance absorption through dielectric and magnetic loss mechanisms. Both experimental and simulated results show that increasing the number of layers improves impedance gradients and broadens the operational bandwidth. The eight-layer coatings demonstrate a more uniform absorption response, while four-layer structures exhibit sharper resonant minima. These findings advance the understanding of ternary multilayer systems and contribute to the development of frequency-selective surfaces and broadband microwave shielding materials. Full article

This review examines the chemical functionalization of Camelina, hemp, and rapeseed oils for the development of sustainable bio-based resins. Key strategies, including epoxidation, acrylation, and click chemistry, are discussed in the context of tailoring molecular structure to enhance reactivity, compatibility, and material performance. Particular emphasis is placed on overcoming the inherent limitations of vegetable oil structures to enable their integration into high-performance polymer systems. The agricultural sustainability and environmental advantages of these feedstocks are also highlighted alongside the technical challenges associated with their chemical modification. Functionalized oils derived from Camelina, hemp, and rapeseed have been successfully applied in various resin systems, including protective coatings, pressure-sensitive adhesives, UV-curable oligomers, and polyurethane foams. These advances demonstrate their growing potential as renewable alternatives to petroleum-based polymers and underline the critical role of structure–property relationships in designing next-generation sustainable materials. Ultimately, the objective of this review is to distill the most effective functionalization pathways and design principles, thereby illustrating how Camelina, hemp, and rapeseed oils could serve as viable substitutes for petrochemical resins in future industrial applications. Full article

Monoterpenes and their derivatives are important starting compounds in the design of new biologically active substances. In particular, cineole, isolated from eucalyptus essential oil, exhibits a wide range of biological activities. Here, the synthesis of new heterocyclic compounds containing a cineole fragment by the acid-catalyzed condensation of α-pinene-derived 8-hydroxy-6-hydroxymethyllimonene with monoterpene aldehydes was carried out for the first time. The reactions of 8-hydroxy-6-hydroxymethyllimonene with cuminaldehyde, perillylaldehyde, myrtenal, citral, and geranial were studied in the presence of heterogeneous K10 clay or Lewis acid BF₃·Et₂O. The main products of these reactions were compounds with the methanopyrano[4,3-b]pyran scaffold having a 1,8-cineole fragment. As a result of this work, five new compounds with the methanopyrano[4,3-b]pyran scaffold were synthesized. The use of BF₃·Et₂O led to an increase in the yields of target products, compared with the results obtained on K10 clay. Full article

A quinoline unit is present in many natural products and is an attractive pharmacophore for the development of clinical drugs, including antineoplastics. The title compound (QN) was synthesized via the condensation reaction between quinoline-2-carboxaldehyde and 2-nitrobenzhydrazide. QN’s structure was examined by X-ray diffraction and features extensive stacking interactions in the crystal. The compound is weakly toxic to HepG2 cells, with an IC₅₀ exceeding 400 μM for 48 h exposure. QN at 50 μM, with the dose reduction index in the range of 1.9–4.4, potentiated the cytotoxicity of several clinical chemotherapeutic drugs, including doxorubicin and other topoisomerase inhibitors, vincristine, and carboplatin, but not cisplatin or 5-fluorouracil. The calculated ADME parameters predict satisfactory drug-like properties for QN. Full article

Levofloxacin is an antibiotic classified as an emerging contaminant. Its presence in aquatic environments represents potential risks to ecosystems and human health, making its removal during wastewater treatment of relevant importance. Here, we present a comprehensive kinetic analysis of levofloxacin photodegradation under UVB solar irradiation, with emphasis on the influence of pH and dissolved oxygen, two conditions that can vary widely in wastewater and impact treatment efficiency. We also investigated the formation and role of reactive oxygen species in the degradation mechanism, as well as the cytotoxicity and antibacterial activity of photoproducts. Our findings reveal that the efficiency of levofloxacin photodegradation is highly dependent on environmental conditions; it requires neutral or slightly alkaline pH and a high concentration of dissolved oxygen, a situation not always observed in contaminated waters. Several reactive oxygen species are generated, with singlet oxygen being the most reactive with the antibiotic. We report for the first time the singlet oxygen quantum yield from levofloxacin. Bioassays demonstrated that photoproducts neither exhibit antibacterial activity nor induce significant cytotoxicity. Our study suggests that UVB treatment of contaminated effluent containing levofloxacin could be an effective and environmentally safe strategy for the antibiotic degradation under certain conditions of pH and dissolved oxygen. Full article

Powders with phase composition including quasi-amorphous phases and calcium carbonate CaCO₃ in the form of calcite or aragonite and sodium halite NaCl as a reaction by-product were synthesized from 0.5M aqua solutions of sodium silicate and 0.5M aqua solutions of calcium and/or magnesium chlorides. Starting solutions were taken in quantities which could provide precipitation of hydrated calcium and/or magnesium silicates with molar ratios Ca/Si = 1 (CaSi), Mg/Si = 1 (MgSi) or (Ca+Mg)/Si = 1 (CaMgSi). Hydrated calcium and/or magnesium silicates, hydrated silica, magnesium carbonate, hydrated magnesium carbonate or hydrated magnesium silicate containing carbonate ions are suspected as components of quasi-amorphous phases presented in synthesized powders. Heat treatment of synthesized powders at 400, 600, 800 °C and pressed preceramic samples at 900, 1000, 1100 and 1200 °C were used for investigation of thermal evolution of the phase composition and microstructure of powders and ceramic samples. Mass loss of powder samples under investigation during heat treatment was provided due to evacuation of H₂O (m/z = 18), CO₂ (m/z = 44) and NaCl at temperatures above its melting point. After sintering at 1100 °C, the phase composition of ceramic samples included wollastonite CaSiO₃ (CaSi_1100); enstatite MgSiO₃, clinoenstatite MgSiO₃ and forsterite Mg₂SiO₄ (MgSi_1100); and diopside CaMgSi₂O₆ (CaMgSi_1100). After sintering at 1200 °C, the phase composition of ceramics CaSi_1200 included pseudo-wollastonite CaSiO₃. After heat treatment at 1300 °C, the phase composition of MgSi_1300 powder included preferably protoenstatite MgSiO₃. The phase composition of all samples after heat treatment belongs to the oxide system CaO–MgO–SiO₂. Ceramic materials in this system are of interest for use in different areas, including refractories, construction materials and biomaterials. Powders prepared in the present investigation, both via precipitation and via heat treatment, can be used for the creation of materials with specific properties and in model experiments as lunar regolith simulants. Full article

In this study, we report the synthesis and characterization of hybrid heterostructures composed of red carbon, an organic semiconductor polymer, and the perovskite (NH₄)₃ZnCl₅. Red carbon was synthesized via the polymerization of carbon suboxide (C₃O₂), exhibiting strong light absorption and distinctive optical properties. The hybrid material was obtained by crystallizing (NH₄)₃ZnCl₅ in the presence of red carbon, leading to significant modifications in the optical characteristics of the perovskite. Comprehensive analyses, including X-ray diffraction, FTIR spectroscopy, UV-vis spectroscopy, and cyclic voltammetry, confirmed the formation of a type I heterostructure with enhanced luminescence and potential for advanced optical applications. The energy band alignment suggests that red carbon can function effectively as both a hole and electron transport medium. This work underscores the potential of (NH₄)₃ZnCl₅@red carbon hybrid heterostructures in the development of next-generation optoelectronic devices, including sensors and LEDs. Full article

This work describes the synthesis, crystal structure, and hydrophobicity tests of four bismuth(III)– and silver(I)–bromide complexes using the triammonium cations diethylenetriaminonium (H₃DETA³⁺) and N,N,N′,N″,N‴-pentamethyldiethylenetriammonium (H₃PMDTA³⁺). The prepared compounds are the 0D perovskites (H₃DETA)[BiBr₆] (1), (H₃DETA)₂[AgBr₄]Br₃ (2), and (H₃PMDTA)[BiBr₆] (3), as well as the 1D/2D mixed perovskite with minimum formula (H₃PMDTA)[Ag₃Br₆] (4), being the last three novel materials. Compounds 1 and 3 crystallize in the orthorhombic P2₁2₁2₁ space group and are discrete [BiBr₆]³⁻ units with the cation surrounding them. In both compounds, the bismuth(III) metal ion is found in a distorted octahedral coordination geometry. Compound 2 crystallizes in the monoclinic P2₁/c space group, and it is a mixed salt consisting of (H₃DETA)[AgBr₄] and (H₃DETA)Br₃, whereas the silver(I) complexes are also isolated. Finally, compound 4, which crystallizes in the orthorhombic space group Pbcn, is a combination of a 2D and 1D silver–bromide perovskite, with the cations filling the voids. The 2D structure has the minimal formula [Ag₄Br₇]³⁻, with the 1D coordination polymer [Ag₂Br₅]³⁻ being both built up by a combination of bromide ions acting as tetrahedra corner and edge-sharing bridging ligands. The silver(I) in 2 and 4 is found in a tetrahedral coordination geometry. All compounds were deposited on pristine FTO glass, resulting in an increase in the contact angle from 22° to 44°, 36°, 62°, and 54° for films of 1, 2, 3, and 4, respectively. Compounds 1 and 3 were also deposited onto Cs₂AgBiBr₆ film, and the contact angles were observed to be the same as when deposited directly onto the FTO cover glass. Full article

The characterization of volatile compounds in cheese is crucial for understanding sensory properties and consumer acceptance. Camembert cheese, a surface-ripened variety, presents a complex aroma profile shaped by biochemical and microbial interactions. Despite advances in analytical methods such as gas chromatography–mass spectrometry (GC–MS) and gas chromatography–olfactometry (GC–O), the metabolic pathways and microbial interactions defining Camembert’s aroma remain incompletely understood. This review explores the synergistic roles of microbial communities, enzymatic activity, and environmental conditions in volatile compound formation. A systematic literature review was conducted using Scopus, Web of Science, and Google Scholar to analyze the classification of volatile compounds, biochemical pathways of aroma formation, and microbial contributions. The findings highlight the essential role of Penicillium camemberti and lactic acid bacteria in aroma modulation, particularly in sulfur compounds, esters, and short-chain fatty acids. Emerging technologies such as solid-phase microextraction (SPME) and metabolomics provide new insights into volatile compound dynamics. Understanding these mechanisms may enhance aroma control in cheese production through microbial engineering and biochemical monitoring. This review underscores the need for integrated approaches to optimize fermentation and ensure sensory standardization, contributing to improved quality and consumer acceptance of Camembert cheese. Full article

One of the most pressing issues confronting modern society is carbon dioxide pollution (CO₂). The reliance of social progress on CO₂-producing technologies such as power generation, automobiles, and specialized industrial processes exacerbates the problem. Due to this reliance, it is critical to develop solutions to reduce CO₂ emissions from these sources. One such solution is carbon capture and sequestration (CCS), which employs chemical methods to prevent CO₂ emissions. The irreversibility of current CCS technology is its primary problem. Chitin, chitosan, and their derivatives, which were recovered from local seafood waste, are studied as reversible CO₂ capture materials in this study in an effort to lessen this issue. Polysulfone (PSF) blends were employed to lessen chitosan edema, as chitosan’s hydrophilicity reduces its active sorption surface. Blends with only 20% chitosan have the same high sorption capacity as pure chitosan due to decreased swelling. Hydrolysis was used to boost the chitin sorption abilities. The CO₂ sorption data were analyzed using an Intelligent Gravimetric Analyzer (IGA), Fourier-Transform Infrared (FTIR) spectroscopy, and Matrix-Assisted Laser Desorption/Ionization-Time of Flight (MALDI-TOF) spectroscopy. This study reveals that shrimp shells were the best source of chitin. This research led to the creation of eco-friendly, reversible, and reusable carbon sequestration sorbents. Full article

Laccases are versatile enzymes capable of oxidizing a wide variety of antibiotics. In this study, the mechanism of catalytic oxidation of first-generation tetracyclines, namely, oxytetracycline, tetracycline, and chlortetracycline, by the Melanocarpus albomyces laccase enzyme was investigated using molecular docking and DFT calculations. Molecular docking studies revealed that all three substrates exhibit negative interaction energies, indicating stable enzyme–substrate complexes, with tetracycline and chlortetracycline showing the highest binding affinities. Global reactivity indices obtained by DFT confirmed the high electrophilicity of the enzyme active site, particularly the aminoacidic residues Glu235 and His508, favoring electron transfer from the substrates. In addition, NBO analysis allowed quantification of the energy of hydrogen bonds in enzyme–substrate interactions, evidencing their key role in the stabilization of the complex. Proton transfer analysis suggested two possible mechanisms: (1) a direct concerted transfer and (2) a process mediated by water molecules. The results provide insights into the thermodynamics, electronic structure, and nature of intermolecular interactions governing the oxidation of tetracyclines by the enzyme, highlighting their potential in bioremediation strategies for antibiotic degradation. Full article

The dinuclear platinum(IV) compound {Pt(CH₃)₃}₂(μ-I)₂(μ-adenine) (abbreviated Pt₂ad), obtained by treating cubic [Pt^IV(CH₃)₃(μ₃-I)]₄ with two equivalents of adenine, was isolated and structurally characterized by single crystal X-ray diffraction. The National Cancer Institute Developmental Therapeutics Program’s in vitro sulforhodamine B assays showed Pt₂ad to be particularly cytotoxic against the central nervous system cancer cell line SF-539, and the human renal carcinoma cell line RXF-393. Furthermore, Pt₂ad displayed some degree of cytotoxicity against non-small cell lung cancer (NCI-H522), colon cancer (HCC-2998, HCT-116, HT29, and SW-620), melanoma (LOX-IMVI, Malme-3M, M14, MDA-MB-435, SK-MEL-28, and UACC-62), ovarian cancer (OVCAR-5), renal carcinoma (A498), and triple negative breast cancer (BT-549, MDA-MB-231, and MDA-MB-468) cells. Although anticancer studies involving some adenine platinum(II) compounds have been reported, this study marks the first assessment of the anticancer activity of an adenine platinum(IV) complex. Full article